Alessandro Gualtieri was born in Milan in 1967 and began training in 1989 at Haarmann & Reimer in Holzminden, Germany, picking up more from an Italian expatriate he met in the town's only bar. Trips to Oman, India and Yemen taught him traditional materials and methods. He spent years composing for Fendi, Versace and Helmut Lang, then worked in-house at Diesel, before settling in Amsterdam and founding Nasomatto, Italian for mad nose, in 2007.
He signs his work The Nose and publishes no note lists. Every Nasomatto bottle is an extrait built around a single intention. Nasomatto Black Afgano, released in 2009, took six years of work to catch the smell of top-grade hashish, and Silver Musk, Duro and Pardon came out of the same house. Orto Parisi followed in 2014: orto is Italian for vegetable garden, and the house is dedicated to his grandfather Vincenzo Parisi, whose garden partly inspired it. Paul Rigter's 2017 documentary The Nose: Searching for Blamage records his work.
His Nasomatto work also includes Narcotic V, built on the pull of female sexual power, Baraonda from 2016, which chases a raw sense of taste, and Micodelirio, a 2026 study of natural, vital delirium. For Orto Parisi he made Megamare, an idea of the open sea and one of his best sellers, and Risvelium, released in 2025 around the idea of awakening.